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Chemical Structure : PA-915
Catalog No.: PC-49382Not For Human Use, Lab Use Only.
PA-915 (PA915) is a small-molecule, non-peptide antagonist of the PACAP type I (PAC1) receptor, inhibits PACAP (1 nM)-induced phosphorylation of CREB in PAC1/CHO cells with IC50 of <10 pM.
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PA-915 (PA915) is a small-molecule, non-peptide antagonist of the PACAP type I (PAC1) receptor, inhibits PACAP (1 nM)-induced phosphorylation of CREB in PAC1/CHO cells with IC50 of <10 pM.
PA-915 is more potent than PA-9 on the PACAP-induced phosphorylation of CREB in the PAC1/CHO cells.
PA-915 inhibited both pituitary adenylate cyclase-activating polypeptide (PACAP) and spinal nerve ligation-induced mechanical allodynia.
PA-915 also showed anti-allodynic effects following oral administration.
| M.Wt | 372.813 | |
| Formula | C17H17ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ichiro Takasaki, et al. Eur J Med Chem. 2020 Jan 15;186:111902.
2. Yusuke Shintani, et al. Biochem Biophys Res Commun. 2022 Nov 26;631:146-151.
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