PAC1 |CAS:2158322-33-7 Probechem Biochemicals

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Chemical Structure : PAC1

PAC1 (Compound PAC1)

Catalog No.: PC-35040Not For Human Use, Lab Use Only.

PAC1 (Compound PAC1) is a novel PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PAC1 (Compound PAC1) is a novel PROTAC antibody conjugate, more potent estrogen receptor-alpha (ERα) degrader compared to PROTAC without antibody conjugation.

Physicochemical Properties

M.Wt	1674.93
Formula	C94H107N13O16
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2S,3S)-8-Cyano-5-((2-methoxynaphthalen-1-yl)methyl)-2-methyl-3-((S)-2-(methylamino)propanamido)-4-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-1-carbonyl)-N-(2-(2-(2-((2-(4-((Z)-1-(4-((4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexan

References

1. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.

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PAC1 (Compound PAC1)

Biological Activity

Physicochemical Properties

References

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