Chemical Structure : PAD-PF2
CAS No.:
PAD-PF2
Catalog No.: PC-24594Not For Human Use, Lab Use Only.
PAD-PF2 is a potent inhibitor of peptidylarginine deiminases (PAD1-4) with IC50 of 42.7 nM for PAD4 mediated citrullination in the fluorescent quenching assay, inhibits all four catalytically active PAD1-4 with comparable potency in a Ca2+-dependent manner.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PAD-PF2 is a potent inhibitor of peptidylarginine deiminases (PAD1-4) with IC50 of 42.7 nM for PAD4 mediated citrullination in the fluorescent quenching assay, inhibits all four catalytically active PAD1-4 with comparable potency in a Ca2+-dependent manner.
PAD-PF2 binds similarly to both PAD4 and PAD2.
PAD-PF2 showed > 80-fold selectivity against a diverse panel of receptors, enzymes, kinases, transporters, and ion channels.
PAD-PF2 inhibits ionomycin induced protein citrullination in human isolated neutrophils.
PAD-PF2 could fully inhibited CitH3 detected protein citrullination with IC50 of 1.0 uM, also able to fully inhibit F95 detected protein citrullination (IC50 = 1.5 uM).
Physicochemical Properties
|
M.Wt
|
484.43
|
|
Formula
|
C25H27Cl2N5O
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-2-amino-2-(1-(5-(3,5-dichloropyridin-2-yl)isoquinolin-1-yl)piperidin-4-yl)-1-(pyrrolidin-1-yl)ethan-1-one
|
References
1. Dakin LA, et al. Nat Commun. 2025 May 16;16(1):4579.
Contact Us
sales@probechem.com
