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Chemical Structure : PAD1 inhibitor 1
Catalog No.: PC-20329Not For Human Use, Lab Use Only.
PAD1 inhibitor 1 is a potent selective Protein Arginine Deiminase 1 (PAD1) inhibitor with IC50 of 18 uM for RFA labelling of PAD1 inhibition, kinact/KI value of 10,400 ± 2,380 M-1min-1.
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PAD1 inhibitor 1 is a potent selective Protein Arginine Deiminase 1 (PAD1) inhibitor with IC50 of 18 uM for RFA labelling of PAD1 inhibition, kinact/KI value of 10,400 ± 2,380 M-1min-1.
PAD1 inhibitor 1 exhibits 74-fold selectivity for PAD1 over the other PADs.
PAD1 inhibitor 1 inhibit histone H3 citrullination in a dose-dependent manner with EC50 of 14.5 uM in HEK293TPAD1 cells in the presence of calcium.
| M.Wt | 635.22 | |
| Formula | C20H20FI2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mondal S, et al. Angew Chem Int Ed Engl. 2019 Sep 2;58(36):12476-12480.
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