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Chemical Structure : PAD4 inhibitor 24
Catalog No.: PC-20330Not For Human Use, Lab Use Only.
PAD4 inhibitor 24 is a highly potent PAD4 inhibitor kinact/KI value of 54,000±3,000, displays >10-fold selectivity for PAD4 over PAD3 and >50-fold over PAD1 and PAD2.
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PAD4 inhibitor 24 is a highly potent PAD4 inhibitor kinact/KI value of 54,000±3,000, displays >10-fold selectivity for PAD4 over PAD3 and >50-fold over PAD1 and PAD2.
PAD4 inhibitor 24 (5-10 uM) inhibits PAD4-mediated H4 citrullination in HL-60 granulocytes after stimulation with the calcium ionophore A23187.
PAD4 inhibitor 24 is more potent than pan-PAD inhibitor Cl-amidine.
| M.Wt | 436.20 | |
| Formula | C18H22Cl4N4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tjin CC, et al. ACS Med Chem Lett. 2018 Sep 14;9(10):1013-1018.
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