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PAD4 inhibitor 24

Chemical Structure : PAD4 inhibitor 24

CAS No.: 2245868-05-5

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PAD4 inhibitor 24

Catalog No.: PC-20330Not For Human Use, Lab Use Only.

PAD4 inhibitor 24 is a highly potent PAD4 inhibitor kinact/KI value of 54,000±3,000, displays >10-fold selectivity for PAD4 over PAD3 and >50-fold over PAD1 and PAD2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PAD4 inhibitor 24 is a highly potent PAD4 inhibitor kinact/KI value of 54,000±3,000, displays >10-fold selectivity for PAD4 over PAD3 and >50-fold over PAD1 and PAD2.
    PAD4 inhibitor 24 (5-10 uM) inhibits PAD4-mediated H4 citrullination in HL-60 granulocytes after stimulation with the calcium ionophore A23187.
    PAD4 inhibitor 24 is more potent than pan-PAD inhibitor Cl-amidine.

    Physicochemical Properties

    M.Wt 436.20
    Formula C18H22Cl4N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-chloro-N-(3-(4,5,6-trichloro-1-(cyclopentylmethyl)-1H-indazol-3-yl)propyl)acetimidamide

    References

    1. Tjin CC, et al. ACS Med Chem Lett. 2018 Sep 14;9(10):1013-1018.

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