Chemical Structure : PAM_16A
CAS No.:
2367645-32-5
PAM_16A
(PAM-16A)
Catalog No.: PC-23881Not For Human Use, Lab Use Only.
PAM_16A is a potent, selective, positive allosteric modulator of TMEM16A (Anoctamin-1, ANO1) with EC50 of 3.6 nM, activates heterologous TMEM16A channels, has no effect on the closely related TMEM16B channel.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PAM_16A is a potent, selective, positive allosteric modulator of TMEM16A (Anoctamin-1, ANO1) with EC50 of 3.6 nM, activates heterologous TMEM16A channels, has no effect on the closely related TMEM16B channel.
PAM_16A is a potent activator that does not interfere with other measurable whole-cell currents in arterial smooth muscle cells (SMCs).
PAM_16A selectively activated TMEM16A currents in SMCs and enhanced aortic contraction caused by phenylephrine or angiotensin-II and capillary (pericyte) constriction evoked by endothelin-1 or oxygen–glucose deprivation (OGD) to simulate cerebral ischaemia.
Physicochemical Properties
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M.Wt
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371.82
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Formula
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C19H18ClN3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-[[2-(5-chloro-2-hydroxy-phenyl)acetyl]amino]-N-(1,1-dimethylprop-2-ynyl)pyridine-2-carboxamide
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References
1. Patent WO2021/014168, compound 1.
2. Al-Hosni R, et al. Br J Pharmacol. 2025 Jan 19. doi: 10.1111/bph.17383.
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