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Chemical Structure : PAP-1
CAS No.: 870653-45-5
Catalog No.: PC-42069Not For Human Use, Lab Use Only.
PAP-1 is a potent, selective small molecule lymphocyte K+ channel Kv1.3 blocker with EC50 of 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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PAP-1 is a potent, selective small molecule lymphocyte K+ channel Kv1.3 blocker with EC50 of 2 nM.
PAP-1 displays 23-fold selectivity over Kv1.5, 33- to 125-fold selectivity over other Kv1-family channels, and 500- to 7500-fold selectivity over Kv2.1, Kv3.1, Kv3.2, Kv4.2, HERG, calcium-activated K+ channels, Na+,Ca2+, and Cl- channels.
PAP-1 potently inhibits the proliferation of human TEM cells and suppresses delayed type hypersensitivity, a TEM cell-mediated reaction, in rats; orally bioavailable.
| M.Wt | 350.3646 | |
| Formula | C21H18O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenoxybutoxy)- |
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1. Schmitz A, et al. Mol Pharmacol. 2005 Nov;68(5):1254-70.
2. Kundu-Raychaudhuri S, et al. J Autoimmun. 2014 Dec;55:63-72.
3. Azam P, et al. J Invest Dermatol. 2007 Jun;127(6):1419-29.
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