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Chemical Structure : PAPTP
Catalog No.: PC-62646Not For Human Use, Lab Use Only.
PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.
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PAPTP is a PAP-1 derivative, potent, specific Kv1.3 channel inhibitor with IC50 of 31 nM in Jurkat T lymphocytes by patch-clamp, reduces cell viability and efficiently kills B16F10 cancer cells at 1 uM.
PAPTP kills 98% of ex vivo primary chronic B-lymphocytic leukemia tumor cells while sparing healthy B cells.
PAPTP significantly reduces tumor size in orthotopic mouse models of melanoma and pancreatic ductal adenocarcinoma.
| M.Wt | 780.639 | |
| Formula | C42H38IO5P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Leanza L, et al. Cancer Cell. 2017 Apr 10;31(4):516-531.e10.
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