PARP-1 inhibitor Pip5

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Chemical Structure : PARP-1 inhibitor Pip5

CAS No.: 2101323-42-4

Catalog No.: PC-21163Not For Human Use, Lab Use Only.

PARP-1 inhibitor Pip5 is an analog of PARP-1 type I inhibitor AZ0108, inhibits PARP-1 auto-PARylation with IC50 of 4-17 nM, shows similar type I inhibition of PARP-1 but is more cytotoxic than AZ0108.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PARP-1 inhibitor Pip5 is an analog of PARP-1 type I inhibitor AZ0108, inhibits PARP-1 auto-PARylation with IC50 of 4-17 nM, shows similar type I inhibition of PARP-1 but is more cytotoxic than AZ0108.

Physicochemical Properties

M.Wt	468.44
Formula	C23H19F3N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-(3-(1,1-difluoroethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

References

1. Moriah R Arnold, et al. Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10.

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