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PARP11 inhibitor ITK7

Chemical Structure : PARP11 inhibitor ITK7

CAS No.: 2411890-36-1

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PARP11 inhibitor ITK7 (ITK7)

Catalog No.: PC-35720Not For Human Use, Lab Use Only.

PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.
    ITK7 exhibits a dose-dependent inhibition of PARP11-dependent auto-MARylation (EC50=13 nM) in HeLa cells, does not inhibit H2O2-activated PARP1 autoPARylation, causes PARP11 to dissociate from the nuclear envelope.

    Physicochemical Properties

    M.Wt 322.386
    Formula C17H14N4OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-methyl-7-(prop-1-yn-1-yl)-2-((pyrimidin-2-ylthio)methyl)quinazolin-4(3H)-one

    References

    1. Kirby IT, et al. Cell Chem Biol. 2018 Oct 18. pii: S2451-9456(18)30331-3

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