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Chemical Structure : PARP11 inhibitor ITK7
Catalog No.: PC-35720Not For Human Use, Lab Use Only.
PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.
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PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.
ITK7 exhibits a dose-dependent inhibition of PARP11-dependent auto-MARylation (EC50=13 nM) in HeLa cells, does not inhibit H2O2-activated PARP1 autoPARylation, causes PARP11 to dissociate from the nuclear envelope.
| M.Wt | 322.386 | |
| Formula | C17H14N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kirby IT, et al. Cell Chem Biol. 2018 Oct 18. pii: S2451-9456(18)30331-3
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