PARP14 inhibitor Q22

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Chemical Structure : PARP14 inhibitor Q22

Catalog No.: PC-24365Not For Human Use, Lab Use Only.

PARP14 inhibitor Q22 is a highly potent, selective poly(ADP-ribose) polymerase 14 (PARP14) inhibitor with IC50 of 5.52 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PARP14 inhibitor Q22 is a highly potent, selective poly(ADP-ribose) polymerase 14 (PARP14) inhibitor with IC50 of 5.52 nM.
Q22 enhances and stabilize PARP14 levels in CFPAC-1 cells under IFN-γ stimulation in CFPAC-1 cells with EC50 of 11.4 nM.
Q22 showes significant therapeutic efficacy in a dinitrochlorobenzene (DNCB)-induced AD mouse model by markedly reducing the expression of key AD-associated inflammatory cytokines, including IL-4, IL-13, and IL-17A.

Physicochemical Properties

M.Wt	426.49
Formula	C23H27FN4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(7-(Cyclopropanecarbonyl)-2,7-diazaspiro[3.5]nonan-2-yl)-7-(cyclopropylmethoxy)-5-fluoroquinazolin-4(3H)-one

References

1. Wu S, et al. J Med Chem. 2025 Apr 16. doi: 10.1021/acs.jmedchem.5c00564.

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