PARP7 inhibitor B-6

Chemical Structure : PARP7 inhibitor B-6

Catalog No.: PC-27584Not For Human Use, Lab Use Only.

PARP7 inhibitor B-6 is a potent, brain-penetrant PARP7 inhibitor with IC50 of 22.8 nM.

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Biological Activity

PARP7 inhibitor B-6 is a potent, brain-penetrant PARP7 inhibitor with IC50 of 22.8 nM.
PARP7 inhibitor B-6 demonstrated efficacy across multiple stroke models, significantly reducing cerebral infarct volume in the rat tMCAO model, and in both the rat tMCAO and mouse dMCAO models, suppressing acute inflammatory cytokine production and promoting sustained neurological and sensorimotor recovery.

Physicochemical Properties

M.Wt	341.27
Formula	C15H11F4N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(3-(4-fluorobenzoyl)azetidin-1-yl)-4-(trifluoromethyl)pyridazin-3(2H)-one

References

1. Yan W, et al. Eur J Med Chem. 2026 Aug 5;318:119184.

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