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PARPYnD

Chemical Structure : PARPYnD

CAS No.: 2561483-27-8

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PARPYnD (PARP photoaffinity probe)

Catalog No.: PC-72910Not For Human Use, Lab Use Only.

PARPYnD is the first cell-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 inhibitor AZ9482.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PARPYnD is the first cell-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 inhibitor AZ9482.
    PARPYnD is a robust tool for profiling PARP1/2 and is used to profile clinical PARP inhibitor olaparib, identifying several novel off-target proteins.
    PARPYnD can enrich recombinant PARP6 spiked into cellular lysates and inhibits PARP6 in cell-free assays, it does not label PARP6 in intact cells.
    PARPYnD inhibits PARP1/2/6 with IC50 of 38/6/230 nM, respectively.

    Physicochemical Properties

    M.Wt 613.68
    Formula C34H31N9O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3-Butyn-1-yl)-N-[5-cyano-6-[4-[3-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]benzoyl]-1-piperazinyl]-3-pyridinyl]-3H-diazirine-3-propanamide

    References

    1. Ryan T Howard, et al. ACS Chem Biol. 2020 Feb 21;15(2):325-333.

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