Chemical Structure : PAV-174
CAS No.:
3034860-02-8
PAV-174
(PAV174)
Catalog No.: PC-25997Not For Human Use, Lab Use Only.
PAV-174 is a host protein-targeted antiviral compound that specifically interacts with an oxidized conformer of MIF (oxMIF), inhibits HSV-1 replication in a dose-dependent manner in HSV-1-infected Vero cells, both in a standard plaque assay and in an in-cell ELISA with an IC50 of 34 or 21 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PAV-174 is a host protein-targeted antiviral compound that specifically interacts with an oxidized conformer of MIF (oxMIF), inhibits HSV-1 replication in a dose-dependent manner in HSV-1-infected Vero cells, both in a standard plaque assay and in an in-cell ELISA with an IC50 of 34 or 21 nM, respectively.
PAV-174 binds MIF at its multimerization interface.
PAV-174 reduces tau phosphorylation also in the absence of infection in an MIF- and dose-dependent manner.
PAV-174 inhibit oxMIF-induced tau phosphorylation in vitro and in 2-month-old male tgTau58/2 mice independent of infection.
Physicochemical Properties
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M.Wt
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414.01
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Formula
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C23H28ClN3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Phenothiazin-5-ium, 1-ethyl-9-methyl-3,7-di-1-pyrrolidinyl-, chloride (1:1)
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References
1. Müller-Schiffmann A, et al. Cell Rep Med. 2025 Dec 18:102520.
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