Catalog No.: PC-49168Not For Human Use, Lab Use Only.
PAV-206 is a novel potent antiretroviral chemotype that inhibits HIV-1 replication with EC50 of 34 nM in HIV-1-infected MT-2 T cells, and 75 nM in HIV-1-infected peripheral blood mononuclear cells (PBMCs), inhibits HIV-1 replication by interfering with HIV-1 assembly.
PAV-206 is a novel potent antiretroviral chemotype that inhibits HIV-1 replication with EC50 of 34 nM in HIV-1-infected MT-2 T cells, and 75 nM in HIV-1-infected peripheral blood mononuclear cells (PBMCs), inhibits HIV-1 replication by interfering with HIV-1 assembly.
PAV-206 acts on the host RNA-granule-related RNP complex that is the precursor of assembly intermediates, even in the absence of Gag, colocalizes with both of host enzymes, ABCE1 and DDX6, in the absence of HIV-1 infection.
PAV-206 is a first-in-class selective inhibitor of HIV-1 assembly that inhibits HIV-1 virus production by selectively acting on host-protein-containing capsid assembly intermediates.
