Chemical Structure : PAV-431
CAS No.:
2019178-91-5
PAV-431
(PAV431)
Catalog No.: PC-22550Not For Human Use, Lab Use Only.
PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.
PAV-431 displayed an EC50 between 25nM and 100nM (depending on the virus) against members of Orthomyxoviridae, Coronaviridae, Paramyxoviridae, Adenoviridae, Herpesviridae, and Picornaviridae-all six families of viruses which cause respiratory disease in humans.
PAV-431 shows efficacy against the WA 1/2020, delta, and omicron strains of SARS CoV-2.
PAV-431 does not show significant activity against rabies virus.
PAV-431 treatment exhibits statistically significant drop in RSV titer in cotton rats infected with respiratory syncytial virus (RSV).
Physicochemical Properties
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M.Wt
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369.34
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Formula
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C17H18F3N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-cyclopropyl-N-(2-methoxy-3-(trifluoromethoxy)benzyl)-1-methyl-1H-pyrazole-5-carboxamide
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References
1. Michon M, et al. bioRxiv [Preprint]. 2023 Dec 12:2021.01.17.426875.
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