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Chemical Structure : PAV-431
Catalog No.: PC-22550Not For Human Use, Lab Use Only.
PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.
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PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.
PAV-431 displayed an EC50 between 25nM and 100nM (depending on the virus) against members of Orthomyxoviridae, Coronaviridae, Paramyxoviridae, Adenoviridae, Herpesviridae, and Picornaviridae-all six families of viruses which cause respiratory disease in humans.
PAV-431 shows efficacy against the WA 1/2020, delta, and omicron strains of SARS CoV-2.
PAV-431 does not show significant activity against rabies virus.
PAV-431 treatment exhibits statistically significant drop in RSV titer in cotton rats infected with respiratory syncytial virus (RSV).
| M.Wt | 369.34 | |
| Formula | C17H18F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Michon M, et al. bioRxiv [Preprint]. 2023 Dec 12:2021.01.17.426875.
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