Chemical Structure : PB221
CAS No.:
1194372-90-1
PB221
(PB-221)
Catalog No.: PC-27723Not For Human Use, Lab Use Only.
PB221 is a selective sigma-2 receptor (σ2R/TMEM97) agonist with Ki of 18.8 nM, shows potent cytotoxic activity against neuroblastoma SK-N-SH cells with IC50 of 3.64 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PB221 is a selective sigma-2 receptor (σ2R/TMEM97) agonist with Ki of 18.8 nM, shows potent cytotoxic activity against neuroblastoma SK-N-SH cells with IC50 of 3.64 uM.
PB221 has IC50 of PB221 for ALTS1C1 and UN-KC6141 cell lines was 10.61 and 13.13 μM, respectively.
PB221 (1 μM) significantly repressed the migration and invasion of ALTS1C1 cells, and a high dose of PB221 (20 μM) resulted in the apoptotic cell death of ALTS1C1 cells.
PB221 effectively retarded tumor growth to 36% of the control tumor volume in the ectopic intramuscular tumor model.
Physicochemical Properties
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M.Wt
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369.59
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Formula
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C25H39NO
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-cyclohexyl-1-(3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl)piperidine
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References
1. Berardi F, et al. J Med Chem. 2009;52(23):7817–7828.
2. Liu CC, et al. BMC Cancer. 2026 Aug 14;26(1):985.
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