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PB28

Chemical Structure : PB28

CAS No.: 172906-90-0

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PB28 (PB-28;PB 28)

Catalog No.: PC-60345Not For Human Use, Lab Use Only.

PB 28 is a potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PB28 is a potent, mixed sigma2 agonist and sigma1 antagonist with Ki of 0.28 and 13.0 nM, respectively.
    PB28 inhibits cancer cell growth, modulates P-glycoprotein, and synergizes with doxorubicin in MCF7 and MCF ADR cells with IC50 in nanomolar range.
    PB28 increases G0-G1-phase fraction and caspase-independent apoptosis, also reduces P-gp expression.

    Physicochemical Properties

    M.Wt 370.57
    Formula C24H38N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine

    References

    1. Azzariti A, et al. Mol Cancer Ther. 2006 Jul;5(7):1807-16.

    2. Cassano G, et al. Cell Calcium. 2006 Jul;40(1):23-8.

    3. Berardi F, et al. J Med Chem. 1996 Jan 5;39(1):176-82.

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