Catalog No.: PC-35464Not For Human Use, Lab Use Only.
PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
PBI-4050 significantly attenuated fibrosis in many injury contexts, as evidenced by the antifibrotic activity observed in kidney, liver, heart, lung, pancreas, and skin fibrosis models;.
PBI-4050 is a first-in-class compound that may be effective for managing inflammatory and fibrosis-related diseases.
Physicochemical Properties
M.Wt
206.285
Formula
C13H18O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(3-pentylphenyl)acetic acid
References
1. Gagnon L, et al. Am J Pathol. 2018 May;188(5):1132-1148.
2. Li Y, et al. JCI Insight. 2018 May 17;3(10). pii: 120365.
