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PBI-4050 sodium

Chemical Structure : PBI-4050 sodium

CAS No.: 1254472-97-3

PBI-4050 sodium (Setogepram sodium, Fezagepras sodium, PBI4050 sodium)

Catalog No.: PC-35465Not For Human Use, Lab Use Only.

PBI-4050 (Setogepram, Fezagepras) sodium is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PBI-4050 (Setogepram, Fezagepras) sodium is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
PBI-4050 significantly attenuated fibrosis in many injury contexts, as evidenced by the antifibrotic activity observed in kidney, liver, heart, lung, pancreas, and skin fibrosis models.
PBI-4050 is a first-in-class compound that may be effective for managing inflammatory and fibrosis-related diseases.

Physicochemical Properties

M.Wt 229.275
Formula C13H18NaO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(3-pentylphenyl)acetic acid, sodium salt

References

1. Gagnon L, et al. Am J Pathol. 2018 May;188(5):1132-1148.

2. Li Y, et al. JCI Insight. 2018 May 17;3(10). pii: 120365.

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