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PBOX-15

Chemical Structure : PBOX-15

CAS No.: 354759-10-7

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PBOX-15 (PBOX15)

Catalog No.: PC-60561Not For Human Use, Lab Use Only.

PBOX-15 is a microtubule targeting agent that induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PBOX-15 is a microtubule targeting agent that induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple cancer cells.
    PBOX-15 radiosensitizes cancer cells in vitro, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours.

    Physicochemical Properties

    M.Wt 417.464
    Formula C28H19NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(naphthalen-1-yl)naphtho[2,3-b]pyrrolo[1,2-d][1,4]oxazepin-4-yl acetate

    References

    1. Mulligan JM, et al. Mol Pharmacol. 2006 Jul;70(1):60-70.

    2. Verma NK, et al. J Mol Med (Berl). 2008 Apr;86(4):457-69.

    3. McElligott AM, et al. Cancer Res. 2009 Nov 1;69(21):8366-75.

    4. Maginn EN, et al. Br J Cancer. 2011 Jan 18;104(2):281-9.

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