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Chemical Structure : PBZ1038
Catalog No.: PC-22848Not For Human Use, Lab Use Only.
PBZ1038 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 1.2 uM against E. faecium GroES/GroEL refolding of malate dehydrogenase (MDH), binds at the GroEL ring–ring interface (RRI).
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PBZ1038 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 1.2 uM against E. faecium GroES/GroEL refolding of malate dehydrogenase (MDH), binds at the GroEL ring–ring interface (RRI).
PBZ1038 engagement of GroES/GroEL in bacteria leads to antibiotic activity.
PBZ1038 potently inhibit the refolding activity of E. coli and the Gram-negative ESKAPE pathogen GroES/GroEL but not the Gram-positive ESKAPE pathogen E. faecium GroES/GroEL.
PBZ1038 shows a robust shift in CC50 in the presence of E. faecium chaperonin and a shift in EC50 in the eGFP reporter assay in the presence of E. faecium chaperonin.
| M.Wt | 537.56 | |
| Formula | C25H19N3O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jack Godek, et al. J Am Chem Soc. 2024 Jul 31;146(30):20845-20856.
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