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Chemical Structure : PC1244
Catalog No.: PC-62607Not For Human Use, Lab Use Only.
PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM.
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PC1244 is a long acting fungicidal azole that targets A. fumigatus CYP51A and CYP51B, inhibits ergosterol synthesis in A. fumigatus with IC50 of 8 nM.
PC1244 demonstrates potent antifungal activities against clinical A. fumigatus isolates with a MIC range of 0.016-0.25 ug/mL.
PC1244 is also effective against a broad spectrum of pathogenic fungi (MIC= <0.0078-2 μg/ml), especially on Aspergillus terreus, Trichophyton rubrum, Candida albicans.
PC1244 shows fungicidal activity (MFC=2 μg/ml), 8-fold more potent than voriconazole.
PC1244 shows superior in vivo effects in immunocompromised mice.
| M.Wt | 686.805 | |
| Formula | C38H44F2N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Colley T, et al. Antimicrob Agents Chemother. 2018 Feb 12. pii: AAC.01941-17.
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