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Chemical Structure : PC786
Catalog No.: PC-60358Not For Human Use, Lab Use Only.
PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.
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PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.
PC786 demonstrates a potent and selective anti-viral activity against laboratory adapted or clinical isolates of RSVA (IC50=<0.09-0.71 nM) and RSVB (IC50=1.3-50.6 nM) without causing detectable cytotoxicity.
| M.Wt | 715.844 | |
| Formula | C41H38FN5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Coates M, et al. Antimicrob Agents Chemother. 2017 Jun 26. pii: AAC.00737-17.
2. Zhao M, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02542-17.
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