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PC786

Chemical Structure : PC786

CAS No.: 1902114-15-1

PC786 (PC 786, PC-786)

Catalog No.: PC-60358Not For Human Use, Lab Use Only.

PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.

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    Biological Activity

    PC786 (PC-786) is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 2.1 nM and 0.5 nM in cell-free enzyme assay and mini-genome assay in HEp-2 cells, respectively.
    PC786 demonstrates a potent and selective anti-viral activity against laboratory adapted or clinical isolates of RSVA (IC50=<0.09-0.71 nM) and RSVB (IC50=1.3-50.6 nM) without causing detectable cytotoxicity.

    Physicochemical Properties

    M.Wt 715.844
    Formula C41H38FN5O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2-yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide

    References

    1. Coates M, et al. Antimicrob Agents Chemother. 2017 Jun 26. pii: AAC.00737-17.

    2. Zhao M, et al. Antimicrob Agents Chemother. 2018 Mar 27;62(4). pii: e02542-17.

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