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Chemical Structure : PC945
CAS No.: 1931946-73-4
Catalog No.: PC-62615Not For Human Use, Lab Use Only.
Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
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| 5 mg | $378 | In stock | |
| 10 mg | $588 | In stock | |
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Opelconazole (PC945) is a novel broad spectrum antifungal agent that potently inhibits Aspergillus fumigatus sterol 14α-demethylase (CYP51A and CYP51B) with IC50 of 0.23 and 0.22 uM, respectively.
Opelconazole (PC945) shows MIC values 0.032 to >8 ug/ml against 96 clinically isolated A. fumigatus strains, demonstrates activity against itraconazole-susceptible and -resistant A. fumigatus growth with IC50 of 0.0012 to 0.034 ug/ml.
Opelconazole (PC945) is a broad spectrum of pathogenic fungi with MIC 0.0078 to 2 ug/ml, and exhibits activity in vivo.
| M.Wt | 682.748 | |
| Formula | C38H37F3N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[4-(4-{[(3R,5R)-5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}-3-methylphenyl)piperazin-1-yl]-N-(4-fluorophenyl)benzamide |
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1. Colley T, et al. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16.
2. Kimura G, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00124-17.
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