PCC-0105002 is a novel small molecule inhibitor of PSD95-nNOS protein-protein interaction with IC50 of 1.4 uM.
PCC-0105002 suppressed mechanical allodynia, thermal hyperalgesia, and abnormal dorsal horn wide dynamic range neuron discharge in the rat spinal nerve ligation (SNL) model.
PCC-0105002 altered signaling downstream of NMDAR and thus functionally and structurally attenuating synaptic plasticity through respective regulation of the NR2B/GluR1/CaMKIIα and Rac1/RhoA pathways.
PCC-0105002 attenuated neuropathic pain without inducing motor dysfunction in animal model.
PCC-0105002 disrupted the PSD95-nNOS interaction in vitro and in vivo.
