PCH-1 | Tubulin inhibitor | Probechem Biochemicals

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Chemical Structure : PCH-1

PCH-1 (Tubulin inhibitor)

Catalog No.: PC-38002Not For Human Use, Lab Use Only.

PCH-1 is a potent antitumor agent that disrupts microtubule assembly, leading to cancer cell death, interacts vinblastine binding site on tubulin.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PCH-1 is a potent antitumor agent that disrupts microtubule assembly, leading to cancer cell death, interacts vinblastine binding site on tubulin.
PCH-1 exhibits the strongest cytotoxic activity through interaction with tubulin, leading to cell cycle arrest and induction of apoptosis.
PCH-1 efficiently inhibits the growth of NSCLC cancer cell lines at micromolar concentrations (A-549 IC50=4.32 uM, H226 IC50=4.69 uM), and non-toxic to normal cells.

Physicochemical Properties

M.Wt	368.389
Formula	C20H20N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(6-methoxybenzo[d][1,3]dioxol-5-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one

References

1. Natalia Maciejewska, et al. Sci Rep. 2022 Mar 8;12(1):3703.

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