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PCI-29732

Chemical Structure : PCI-29732

CAS No.: 330786-25-9

PCI-29732 (PCI29732;PCI 29732)

Catalog No.: PC-45400Not For Human Use, Lab Use Only.

APCI-29732 is a potent, selective and irreversible Btk inhibitor with biochemical Ki of 8.2 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PCI-29732 is a potent, selective and irreversible Btk inhibitor with biochemical Ki of 8.2 nM.
PCI-29732 also inhibits Lck and Lyn with Ki of 4.6 and 2.5 nM, respectively.

Physicochemical Properties

M.Wt 371.435
Formula C22H21N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 53 mg/mL

Chemical Name/SMILES

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-cyclopentyl-3-(4-phenoxyphenyl)-

References

1. Pan Z, et al. ChemMedChem. 2007 Jan;2(1):58-61.

2. Honigberg LA, et al. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

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