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PCI-32765 racemate

Chemical Structure : PCI-32765 racemate

CAS No.: 936563-87-0

PCI-32765 racemate (Ibrutinib Racemate;PCI32765 Racemate;PCI 32765 Racemate)

Catalog No.: PC-42773Not For Human Use, Lab Use Only.

A potent a+M7692nd highly selective Btk inhibitor with IC50 of 0.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent a+M7692nd highly selective Btk inhibitor with IC50 of 0.5 nM; modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc.

Blood Cancer

Approved

Physicochemical Properties

M.Wt 440.4971
Formula C25H24N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Propen-1-one, 1-[3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-

References

1. Honigberg LA, et al. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

2. Herman SE, et al. Blood. 2014 May 22;123(21):3286-95.

3. Kohrt HE, et al. Blood. 2014 Mar 20;123(12):1957-60.

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