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Chemical Structure : PCI-34051
CAS No.: 950762-95-5
Catalog No.: PC-22427Not For Human Use, Lab Use Only.
PCI-34051 is a potent, specific HDAC8 inhibitor with IC50 of 10 nM, >200-fold selectivity over other HDAC isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $28 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote |
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PCI-34051 is a potent, specific HDAC8 inhibitor with IC50 of 10 nM, >200-fold selectivity over other HDAC isoforms.
PCI-34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias, but not in other hematopoietic or solid tumor lines.
PCI-34051 does not cause detectable histone or tubulin acetylation.
PCI-34051 has a unique mechanism of action involving PLCγ1 activation and calcium-induced apoptosis.
| M.Wt | 296.33 | |
| Formula | C17H16N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-Hydroxy-1-(4-methoxybenzyl)-1H-indole-6-carboxamide |
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1. Balasubramanian S, et al. Leukemia. 2008 May;22(5):1026-34.
2. Ha SD, et al. J Immunol. 2014 Aug 1;193(3):1333-43.
3. Dasgupta T, et al. J Biol Chem. 2016 Jun 10;291(24):12761-12770.
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