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Chemical Structure : PCNA-I1
CAS No.: 444930-42-1
Catalog No.: PC-38448Not For Human Use, Lab Use Only.
PCNA-I1 is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), selectively binds to PCNA trimers with Kd of 0.14-0.41 uM, inhibits the growth of tumor cells of various tissue types with IC50 of 0.2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
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| 100 mg | Get quote |
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PCNA-I1 is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), selectively binds to PCNA trimers with Kd of 0.14-0.41 uM, inhibits the growth of tumor cells of various tissue types with IC50 of 0.2 uM.
PCNA-I1 dose- and time-dependently reduced the chromatin-associated PCNA in cells, affected the growth of nontransformed cells at significantly higher concentrations (IC50=1.6 uM).
PCNA-I1 also dose-dependently reduced uptake of BrdU in PCNA-I1 treated cells, induced cancer cell arrest at both the S and G(2)/M phases.
PCNA-I1 induced DNA damage and apoptosis in both LNCaP (wild-type p53) and PC-3 cells (p53-null) and enhanced DNA damage and apoptosis triggered by cisplatin, also induced autophagy in PC-3 cells.
PCNA-I1 (i,v.) significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles.
| M.Wt | 310.37 | |
| Formula | C17H14N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Thiophenecarboxylic acid, 3-methyl-, 2-[(1-hydroxy-2-naphthalenyl)methylene]hydrazide |
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1. Tan Z, et al. Mol Pharmacol. 2012 Jun;81(6):811-9.
2. Dillehay KL, et al. Mol Cancer Ther. 2014 Dec;13(12):2817-26.
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