Catalog No.: PC-38448Not For Human Use, Lab Use Only.
PCNA-I1 is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), selectively binds to PCNA trimers with Kd of 0.14-0.41 uM, inhibits the growth of tumor cells of various tissue types with IC50 of 0.2 uM.
PCNA-I1 is a small molecule inhibitor of proliferating cell nuclear antigen (PCNA), selectively binds to PCNA trimers with Kd of 0.14-0.41 uM, inhibits the growth of tumor cells of various tissue types with IC50 of 0.2 uM.
PCNA-I1 dose- and time-dependently reduced the chromatin-associated PCNA in cells, affected the growth of nontransformed cells at significantly higher concentrations (IC50=1.6 uM).
PCNA-I1 also dose-dependently reduced uptake of BrdU in PCNA-I1 treated cells, induced cancer cell arrest at both the S and G(2)/M phases.
PCNA-I1 induced DNA damage and apoptosis in both LNCaP (wild-type p53) and PC-3 cells (p53-null) and enhanced DNA damage and apoptosis triggered by cisplatin, also induced autophagy in PC-3 cells.
PCNA-I1 (i,v.) significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles.
