PCSK9-IN-7l |CAS:1632250-31-7 Probechem Biochemicals

Chemical Structure : PCSK9-IN-7l

Catalog No.: PC-35186Not For Human Use, Lab Use Only.

PCSK9-IN-7l is a potent, small molecule PCSK9 mRNA translation inhibitor with IC50 of 1.37 uM, shows limited bone marrow toxicity (IC50=27.1 uM)..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PCSK9-IN-7l is a potent, small molecule PCSK9 mRNA translation inhibitor with IC50 of 1.37 uM, shows limited bone marrow toxicity (IC50=27.1 uM).

M.Wt	448.915
Formula	C22H21ClN8O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-chloropyridin-2-yl)-5-(6-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-[(3R)-piperidin-3-yl]pyridine-2-carboxamide

1. Londregan AT, et al. J Med Chem. 2018 Jun 7. doi: 10.1021/acs.jmedchem.8b00650.