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PCSK9 inhibitor 9

Chemical Structure : PCSK9 inhibitor 9

CAS No.: 2215931-60-3

PCSK9 inhibitor 9

Catalog No.: PC-38279Not For Human Use, Lab Use Only.

PCSK9 inhibitor 9 is a small-molecule ligand with high affinity for a novel allosteric binding site on PCSK9.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PCSK9 inhibitor 9 is a small-molecule ligand with high affinity for a novel allosteric binding site on PCSK9.
    PCSK9 inhibitor 9 showed good target engagement with PCSK9 in Huh7 cell lysate.

    Physicochemical Properties

    M.Wt 631.719
    Formula C34H34FN3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2'-fluoro-4'-(((1R)-1-methyl-1-(2-oxo-2-(thiazol-2-ylamino)ethyl)-6-((tetrahydro-2H-pyran-2-yl)methoxy)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)-[1,1'-biphenyl]-4-carboxylic acid

    References

    1. Whitney L Petrilli, et al. Cell Chem Biol. 2020 Jan 16;27(1):32-40.e3.

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