Chemical Structure : PCSK9 inhibitor Pep2-8
CAS No.: 1541011-97-5
Catalog No.: PC-25615Not For Human Use, Lab Use Only.
Pep2-8 is a specific small peptide PCSK9 inhibitor with a binding KD of 0.7 μM, inhibits LDL receptor and EGF(A) domain binding to PCSK9 with IC50 values of 0.8 μMand 0.4 μM respectively, Pep2-8 is an EGF(A)-mimicking peptide and does not bind to other proprotein convertases.
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Pep2-8 is a specific small peptide PCSK9 inhibitor with a binding KD of 0.7 μM, inhibits LDL receptor and EGF(A) domain binding to PCSK9 with IC50 values of 0.8 μMand 0.4 μM respectively, Pep2-8 is an EGF(A)-mimicking peptide and does not bind to other proprotein convertases.
M.Wt | 1715.85 | |
Formula | C83H110N16O24 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 |
1. Zhang Y, et al. J Biol Chem. 2014 Jan 10;289(2):942-55.
2. Zhang Y, et al. Nat Struct Mol Biol. 2017 Oct;24(10):848-856.
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