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PCSK9 inhibitor Pep2-8

Chemical Structure : PCSK9 inhibitor Pep2-8

CAS No.: 1541011-97-5

PCSK9 inhibitor Pep2-8

Catalog No.: PC-25615Not For Human Use, Lab Use Only.

Pep2-8 is a specific small peptide PCSK9 inhibitor with a binding KD of 0.7 μM, inhibits LDL receptor and EGF(A) domain binding to PCSK9 with IC50 values of 0.8 μMand 0.4 μM respectively, Pep2-8 is an EGF(A)-mimicking peptide and does not bind to other proprotein convertases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pep2-8 is a specific small peptide PCSK9 inhibitor with a binding KD of 0.7 μM, inhibits LDL receptor and EGF(A) domain binding to PCSK9 with IC50 values of 0.8 μMand 0.4 μM respectively, Pep2-8 is an EGF(A)-mimicking peptide and does not bind to other proprotein convertases.

Physicochemical Properties

M.Wt 1715.85
Formula C83H110N16O24
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2

References

1. Zhang Y, et al. J Biol Chem. 2014 Jan 10;289(2):942-55.

2. Zhang Y, et al. Nat Struct Mol Biol. 2017 Oct;24(10):848-856.

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