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PCSK9 modulator 10

Chemical Structure : PCSK9 modulator 10

CAS No.: 1874254-18-8

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PCSK9 modulator 10

Catalog No.: PC-63170Not For Human Use, Lab Use Only.

PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PCSK9 modulator 10 is a highly potent, orally active PCSK9 modulator that inhibits PCSK9 production in HepG2 cells with IC50 of 0.036 nM.
    PCSK9 modulator 10 significantly reduces LDL-c levels by 46% and 57% at 0.01 and 0.04 mg/kg in vivo without deaths or abnormal general signs.

    Physicochemical Properties

    M.Wt 365.659
    Formula C15H6ClF6NO
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-chloro-6-(trifluoromethyl)-2-(4-(trifluoromethyl)phenyl)benzo[d]oxazole

    References

    1. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3.

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