PCW-A1001 | FLT3 D835Y inhibitor | Probechem Biochemicals

Chemical Structure : PCW-A1001

PCW-A1001 (FLT3 D835Y mutant inhibitor)

Catalog No.: PC-20211Not For Human Use, Lab Use Only.

PCW-A1001 is a potent, selective inhibitor of FLT-3 (D835Y) mutant with IC50 of 764 nM, weakly inhibits WT FLT-3 with IC50 of 2.54 uM.

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Biological Activity

PCW-A1001 is a potent, selective inhibitor of FLT-3 (D835Y) mutant with IC50 of 764 nM, weakly inhibits WT FLT-3 with IC50 of 2.54 uM.
PCW-A1001 inhibited the proliferation of MV4-11 cells with IC50 of 1.98 uM.

Physicochemical Properties

M.Wt	394.52
Formula	C23H30N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(tert-butyl)-N-(4-carbamoyl-3-(piperidin-3-ylamino)phenyl)benzamide

References

1. Seong Hun Jang, et al. Front Mol Biosci. 2022 Nov 25;9:1072028.

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PCW-A1001 (FLT3 D835Y mutant inhibitor)

Biological Activity

Physicochemical Properties

References

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