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Chemical Structure : PD-118057
CAS No.: 313674-97-4
Catalog No.: PC-60840Not For Human Use, Lab Use Only.
PD-118057 is a potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells.
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|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
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| 100 mg | Get quote |
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PD-118057 is a potent, selective hERG potassium channel (Kv11.1) activator that increases peak tail hERG current of 111.1% at 10 uM in HEK293 cells.
PD-118057 does not ot affect the voltage dependence and kinetics of gating parameters, and open conformation of the channel, also shows no major effect on I(Na), I(Ca,L), I(K1), and I(Ks).
PD-118057 shortens the action potential duration and QT interval in arterially perfused rabbit ventricular wedge preparation, prevents action potential duration and QT prolongation caused by dofetilide at 3 uM.
| M.Wt | 386.272 | |
| Formula | C21H17Cl2NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-{4-[2-(3,4-dichloro-phenyl)-ethyl]-phenylamino}-benzoic acid |
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1. Zhou J, et al. Mol Pharmacol. 2005 Sep;68(3):876-84. Epub 2005 Jun 23.
2. Patel C, et al. Heart Rhythm. 2008 Apr;5(4):585-90.
3. Perry M, et al. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20075-80.
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