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Chemical Structure : PD-1 inhibitor SCL-1
Catalog No.: PC-49402Not For Human Use, Lab Use Only.
PD-1 inhibitor SCL-1 is a potent small molecule inhibitor of PD-1/PD-L1 binding and exerts potent antitumor effects.
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PD-1 inhibitor SCL-1 is a potent small molecule inhibitor of PD-1/PD-L1 binding and exerts potent antitumor effects.
PD1 inhibitor SCL-1 binds near the PD-1/PD-L1 interface and form hydrogen bonds with Ser62, Asn66, and Lys78 of PD-1.
PD1 inhibitor SCL-1 exhibited moderate inhibitory activities against PD-1/PD-L1 binding compared to an anti-PD-1 antibody, SCL-1 exerted markedly weaker cytotoxic effects on target cells.
PD1 inhibitor SCL-1 (50 mg/kg) exerted significant antitumor effects on PD-L1+ SCC-3 tumors, which were dependent on CD8+ T cell infiltration and PD-L1 expression in tumors.
| M.Wt | 396.418 | |
| Formula | C18H23F3N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Akiyama Y, et al. Anticancer Res. 2022 Nov;42(11):5233-5247.
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