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Chemical Structure : PD-307243
Catalog No.: PC-60834Not For Human Use, Lab Use Only.
A potent hERG channel activator that concentration-dependently increases the hERG current (2.1 and 3.4-fold at 3 and 10 uM, respectively) and markedly slows hERG channel deactivation and inactivation.
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PD-307243 (PD307243) is a potent hERG channel activator that concentration-dependently increases the hERG current (2.1 and 3.4-fold at 3 and 10 uM, respectively) and markedly slows hERG channel deactivation and inactivation.
PD-307243 induces instantaneous hERG current with little decay at membrane potentials from -120 to -40 mV at 3 and 10 uM, induces an I(to)-like upstroke of hERG current at more positive voltages.
PD-307243 slows the channel deactivation but has no effect on channel activation.
| M.Wt | 400.259 | |
| Formula | C20H15Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gordon E, et al. Mol Pharmacol. 2008 Mar;73(3):639-51.
2. Xu X, et al. Mol Pharmacol. 2008 Jun;73(6):1709-21.
3. Donovan BT, et al. Eur J Pharmacol. 2018 Jan 5;818:306-327.
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