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Chemical Structure : PD-L1/CD73 inhibitor CC5
Catalog No.: PC-22369Not For Human Use, Lab Use Only.
PD-L1/CD73 inhibitor CC5 is a potent, dual PD-L1/CD73 inhibitor with IC50 of 6 nM/773 nM for PD-L1/CD73, respectively.
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PD-L1/CD73 inhibitor CC5 is a potent, dual PD-L1/CD73 inhibitor with IC50 of 6 nM/773 nM for PD-L1/CD73, respectively.
CC5 shows high affintiy for PD-L1 with SPR Kd of 182 nM for human PD-L1, 101 nM for CD73, respectively.
CC-5 significantly suppressed tumor growth in a CT26 and B16-F10 tumor model with TGI of 64.3% and 39.6%, respectively.
CC-5 exerted anticancer effects via activating the tumor immune microenvironment.
| M.Wt | 837.38 | |
| Formula | C47H45ClN8O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shuanghu Wang, et al. J Med Chem. 2024 May 15. doi: 10.1021/acs.jmedchem.4c00553.
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