PD-L1/CD73 inhibitor CC5

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Chemical Structure : PD-L1/CD73 inhibitor CC5

Catalog No.: PC-22369Not For Human Use, Lab Use Only.

PD-L1/CD73 inhibitor CC5 is a potent, dual PD-L1/CD73 inhibitor with IC50 of 6 nM/773 nM for PD-L1/CD73, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PD-L1/CD73 inhibitor CC5 is a potent, dual PD-L1/CD73 inhibitor with IC50 of 6 nM/773 nM for PD-L1/CD73, respectively.
CC5 shows high affintiy for PD-L1 with SPR Kd of 182 nM for human PD-L1, 101 nM for CD73, respectively.
CC-5 significantly suppressed tumor growth in a CT26 and B16-F10 tumor model with TGI of 64.3% and 39.6%, respectively.
CC-5 exerted anticancer effects via activating the tumor immune microenvironment.

Physicochemical Properties

M.Wt	837.38
Formula	C47H45ClN8O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-Chloro-2-((2-(4-(6-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)pyridazin-3-yl)piperazine-1-carbonyl)piperidin-1-yl)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)benzonitrile

References

1. Shuanghu Wang, et al. J Med Chem. 2024 May 15. doi: 10.1021/acs.jmedchem.4c00553.

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