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PD-L1 inhibitor 4

Chemical Structure : PD-L1 inhibitor 4

CAS No.: 2375674-19-2

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PD-L1 inhibitor 4 (PD-L1-IN-4)

Catalog No.: PC-73047Not For Human Use, Lab Use Only.

PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.
    PD-L1 inhibitor 4 exhibited substantially increased binding affinity to hPD-L1, as well as PD-1/PD-L1 inhibitory activity in physiological conditions.
    PD-L1 inhibitor 4 also showed a dose-dependent increase in IFN-γ secretion levels in a mixed lymphocyte reaction assay.

    Physicochemical Properties

    M.Wt 892.966
    Formula C50H48N6O10
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,2'R)-2,2'-((((((2,2'-dimethyl-[1,1'-biphenyl]-3,3'-diyl)bis(methylene))bis(oxy))bis(2-((5-cyanopyridin-3-yl)methoxy)-4,1-phenylene))bis(methylene))bis(azanediyl))bis(3-hydroxypropanoic acid)

    References

    1. Kawashita S, et al. Bioorg Med Chem Lett. 2019 Sep 1;29(17):2464-2467.

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