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Chemical Structure : PD-L1 inhibitor 4
Catalog No.: PC-73047Not For Human Use, Lab Use Only.
PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.
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PD-L1 inhibitor 4 is a small molecule inhibitor of PD-1/PD-L1 with SPR KD of 0.079 nM.
PD-L1 inhibitor 4 exhibited substantially increased binding affinity to hPD-L1, as well as PD-1/PD-L1 inhibitory activity in physiological conditions.
PD-L1 inhibitor 4 also showed a dose-dependent increase in IFN-γ secretion levels in a mixed lymphocyte reaction assay.
| M.Wt | 892.966 | |
| Formula | C50H48N6O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kawashita S, et al. Bioorg Med Chem Lett. 2019 Sep 1;29(17):2464-2467.
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