PD144418 is a potent, selective sigma 1 ligand with Ki of 0.08 nM, >3000-fold selectivity over sigma 2 (Ki=1377 nM).
PD144418 displays lacked affinity for dopaminergic, adrenergic, muscarinic and a variety of other receptors.
PD144418 reverses the NMDA-induced increase in cGMP in rat cerebellar slices without affecting the basal levels, potentiates the decrease in 5-hydroxytryptophan caused by haloperidol in the mesolimbic region in rats.
PD144418 antagonizes mescaline-induced scratching withour effect on spontaneous motor activity.
