PD150606 is a potent and selective calpain inhibitor with Ki of 0.21 uM/0.37 uM for u-calpain/m-calpain, respectively.
PD150606 shows no inhibition for other proteases (cathepin B, papain, trypsin and thermolysin (Ki> 500 uM).
PD150606 attenuate shypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices.
