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PD151746

Chemical Structure : PD151746

CAS No.: 181765-30-0

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PD151746 (PD 151746, PD-151746)

Catalog No.: PC-45704Not For Human Use, Lab Use Only.

PD151746 (PD 151746) is a potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PD151746 (PD 151746) is a potent, selective, cell-permeable Calpain inhibitor with Ki of 0.26 uM for m-calpain.
PD151746 displays 20-fold selectivity over m-calpain; attenuates the SLLVY-AMC hydrolysis induced by maitotoxin in SY5Y cells.
PD151746 decreases cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells.

Physicochemical Properties

M.Wt 237.2501
Formula C11H8FNO2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 37 mg/mL
Chemical Name/SMILES

(Z)-3-(5-fluoro-1H-indol-3-yl)-2-mercaptoacrylic acid

References

1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6687-92.

2. Porn-Ares MI, et al. Biochem J. 2003 Sep 1;374(Pt 2):403-11.

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