PD173952 | Bcr-Abl inhibitor | Probechem Biochemicals

Chemical Structure : PD173952

CAS No.: 305820-75-1

PD173952 (PD 173952 )

Catalog No.: PC-22637Not For Human Use, Lab Use Only.

PD173952 is a multi-kinases inhibitor with IC50 of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk kinase respectively, induces apoptosis of Bcr-Abl-dependent hematopoietic cells.

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Biological Activity

PD173952 is a multi-kinases inhibitor with IC50 of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk kinase respectively, induces apoptosis of Bcr-Abl-dependent hematopoietic cells.

Physicochemical Properties

M.Wt	482.37
Formula	C24H21Cl2N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2,6-Dichlorophenyl)-8-methyl-2-[[4-(4-morpholinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

References

1. Dorsey JF, et al. Leukemia. 2002 Sep;16(9):1589-95.

2. Marshall SJ, et al. Blood. 2004 Apr 1;103(7):2601-9.

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PD173952 (PD 173952 )

Biological Activity

Physicochemical Properties

References

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