PDE1-IN-4

Chemical Structure : PDE1-IN-4

Catalog No.: PC-28608Not For Human Use, Lab Use Only.

PDE1-IN-4 (compound 2g) is a potent and selective phosphodiesterase-1 (PDE1) inhibitor with IC50 of 10 nM, 145 nM, and 354 nM for PDE1C, PDE1A, and PDE1B respectively.

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Biological Activity

PDE1-IN-4 (compound 2g) is a potent and selective phosphodiesterase-1 (PDE1) inhibitor with IC50 of 10 nM, 145 nM, and 354 nM for PDE1C, PDE1A, and PDE1B respectively.
PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1.
PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP and cGMP in the lungs of rats with pulmonary fibrosis.

Physicochemical Properties

M.Wt	535.63
Formula	C33H33N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(1-methyl-1H-indazol-5-yl)-, 3,5-bis[(1R)-1-phenylethyl] ester

References

1. Huang MX, et al. J Med Chem. 2022 Jun 23;65(12):8444-8455.

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PDE1-IN-4

Biological Activity

Physicochemical Properties

References

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