PDE11A4 inhibitor 15c

Chemical Structure : PDE11A4 inhibitor 15c

Catalog No.: PC-27123Not For Human Use, Lab Use Only.

PDE11A4 inhibitor 15c is a potent, selective PDE11A4 inhibitor with IC50 of 33 nM.

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Biological Activity

PDE11A4 inhibitor 15c is a potent, selective PDE11A4 inhibitor with IC50 of 33 nM.
PDE11A4 inhibitor 15c displays excellent selectivity for PDE11A4 over PDEs 3, 4, 5, 6 and 10.
PDE11A4 inhibitor 15c displays both good aqueous solubility and high microsomal stability.
PDE11A4 inhibitor 15c reduces both cAMP-PDE11A4 activity (EC50 10.2 μM) and cGMP-PDE11A4 activity (EC50 10.4 μM) in a concentration-dependent manner.
PDE11A4 inhibitor 15c reverses the aging-like LLPS of mPDE11A4 in HT22 neuronal cells and LLPS of human PDE11A4 (hPDE11A4) in human SH-SY5Y neuronal cells.

Physicochemical Properties

M.Wt	430.49
Formula	C23H23FN8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(4-((3-fluorophenyl)amino)-5-(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)piperidin-1-yl)acetonitrile

References

1. Mahmood SU, et al. ACS Med Chem Lett. 2026 Jan 30;17(2):547-553.