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PDE12-IN-3

Chemical Structure : PDE12-IN-3

CAS No.: 1803357-22-3

PDE12-IN-3

Catalog No.: PC-60875Not For Human Use, Lab Use Only.

A potent phosphodiesterase 12 (PDE12) with Ki of 17.5 nM, with no activity for related enzyme CNOT6 (Ki>10 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent phosphodiesterase 12 (PDE12) with Ki of 17.5 nM, with no activity for related enzyme CNOT6 (Ki>10 uM); exhibits antiviral activity comparable with the effects observed with PDE12 gene inactivation.

Physicochemical Properties

M.Wt 491.551
Formula C29H25N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(6-(3-(hydroxymethyl)-2-phenylmorpholine-4-carbonyl)-1-methyl-1H-benzo[d]imidazol-2-yl)-1H-indole-6-carbonitrile

References

1. Wood ER, et al. J Biol Chem. 2015 Aug 7;290(32):19681-96.

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