PDE12-IN-3 |CAS:1803357-22-3 Probechem Biochemicals

Chemical Structure : PDE12-IN-3

PDE12-IN-3

Catalog No.: PC-60875Not For Human Use, Lab Use Only.

PDE12-IN-3 is a potent phosphodiesterase 12 (PDE12) with Ki of 17.5 nM, with no activity for related enzyme CNOT6 (Ki>10 uM).

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Biological Activity

PDE12-IN-3 is a potent phosphodiesterase 12 (PDE12) with Ki of 17.5 nM, with no activity for related enzyme CNOT6 (Ki>10 uM).
PDE12-IN-3 exhibits antiviral activity comparable with the effects observed with PDE12 gene inactivation.

Physicochemical Properties

M.Wt	491.551
Formula	C29H25N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(6-(3-(hydroxymethyl)-2-phenylmorpholine-4-carbonyl)-1-methyl-1H-benzo[d]imidazol-2-yl)-1H-indole-6-carbonitrile

References

1. Wood ER, et al. J Biol Chem. 2015 Aug 7;290(32):19681-96.

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PDE12-IN-3

Biological Activity

Physicochemical Properties

References

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