Chemical Structure : PDE12 inhibitor Compound 1
CAS No.:
2259620-80-7
PDE12 inhibitor Compound 1
Catalog No.: PC-20981Not For Human Use, Lab Use Only.
PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6.
PDE12 inhibitor Compound 1 produced increase in 2',5'-oligoadenylate (2-5A) levels in HeLa cells with pEC50 of 7.7.
PDE12 inhibitor Compound 1 inhibited the EMCV-induced cytopathic effect in HeLa Ohio cells with a pIC50 of 6.7.
PDE12 inhibitor Compound 1 inhibited HeLa Ohio cell proliferation in the absence of EMCV infection with a pIC50 of 5.7.
PDE12 inhibitor Compound 1 inhibited HRV infection with a pIC50 of 6.9.
Physicochemical Properties
|
M.Wt
|
616.49
|
|
Formula
|
C31H27BrFN5O3
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N#CC1=CC2=C(C=C1)C(C3=NC4=CC(Br)=C(C(N5[C@@H](CO)[C@H](C6=CC=C(F)C=C6)OCC5)=O)C=C4N3C)=CN2CC
|
References
1. Wood ER, et al. J Biol Chem. 2015 Aug 7;290(32):19681-96.
Contact Us
sales@probechem.com
