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Chemical Structure : PDE12 inhibitor Compound 1
Catalog No.: PC-20981Not For Human Use, Lab Use Only.
PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6.
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PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6.
PDE12 inhibitor Compound 1 produced increase in 2',5'-oligoadenylate (2-5A) levels in HeLa cells with pEC50 of 7.7.
PDE12 inhibitor Compound 1 inhibited the EMCV-induced cytopathic effect in HeLa Ohio cells with a pIC50 of 6.7.
PDE12 inhibitor Compound 1 inhibited HeLa Ohio cell proliferation in the absence of EMCV infection with a pIC50 of 5.7.
PDE12 inhibitor Compound 1 inhibited HRV infection with a pIC50 of 6.9.
| M.Wt | 616.49 | |
| Formula | C31H27BrFN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wood ER, et al. J Biol Chem. 2015 Aug 7;290(32):19681-96.
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