PDE1 inhibitor 3f

Chemical Structure : PDE1 inhibitor 3f

Catalog No.: PC-23410Not For Human Use, Lab Use Only.

PDE1 inhibitor 3f is a potent, selective PDE1 inhibitor with IC50 of 11 nM, >24-fold selectivity over other PDEs, shows antifibrotic effects in vivo and in vitro.

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Biological Activity

PDE1 inhibitor 3f is a potent, selective PDE1 inhibitor with IC50 of 11 nM, >24-fold selectivity over other PDEs, shows antifibrotic effects in vivo and in vitro.

Physicochemical Properties

M.Wt	408.32
Formula	C17H11Cl2N3OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((1-(3-Chlorophenyl)ethyl)thio)-4-(5-chlorothiophen-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

References

1. Jiang MY, et al. J Med Chem. 2024 Nov 15. doi: 10.1021/acs.jmedchem.4c01533.

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